研究员
分子医学研究所
北大-清华生命科学联合中心
个人简介
主要研究代谢和免疫系统的交互作用，目前专注于能量代谢的免疫调控机制，试图深入了解免疫系统在组织和动物整体水平上如何调控代谢系统。以小鼠为模式动物，综合使用分子、细胞、遗传、代谢和免疫学等手段来探究不同免疫细胞在关键代谢组织（如脂肪、肝脏及胰腺）中的功能和相互作用范式，目标是揭示它们的细胞分子机制，为开发新的、更有效的治疗肥胖和代谢综合征的方法策略提供理论基础。在Cell, Nature, Nature Immunology等国际一流期刊发表多篇论文。
所授课程
本科生：
《分子医学高级教程》（选修，3学分）
研究生：
《代谢生物学》（选修，3学分）
《能量代谢的免疫调控》（选修，3学分）
《糖脂代谢研究进展》（选修，3学分）
教育背景
1996.9 - 2000.7 南昌大学生物系，学士
2003.9 - 2010.3 中科院上海生命科学研究院，博士
工作简历
2010.11 – 2015.10 加州大学旧金山分校，博士后
2015.11 – 现在 威斯尼斯人615CC棋牌未来技术学院，研究员
承担项目
n 国家自然科学基金面上项目 (课题负责人)
n 国家自然科学基金重大研究计划 (课题负责人)
n 科技部重点研发计划（课题骨干）
代表性论文
1. Jingfei Yao, Dongmei Wu, Chunyan Zhang, Ting Yan, Yiheng Zhao, Hongyu Shen, Kaili Xue, Xun Huang, Zihao Wang and Yifu Qiu#. Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation. Nature Immunology (In press). (#corresponding author).
2. Yifu Qiu, Khoa D. Nguyen, Justin I. Odegaard, Xiaojin Cui, Xiaoyu Tian, Richard M. Locksley, Richard D. Palmiter, Ajay Chawla. Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat. Cell, 157, 1292–1308 (2014).
3. Khoa D. Nguyen*, Yifu Qiu*, Xiaojin Cui, Y. P. Sharon Goh, Julia Mwangi, Tovo David, Lata Mukundan, Frank Brombacher, Richard M. Locksley & Ajay Chawla. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature, 480, 104-108 (2011). (*equal contribution).
4. Yifu Qiu, Ting Mao, Yongliang Zhang, Mengle Shao, Jia You, Qiurong Ding, Yan Chen, Dongmei Wu, Dong Xie, Xu Lin, Xiang Gao, Randal J. Kaufman, Wenjun Li, Yong Liu. A crucial role for RACK1 in regulation of glucose-stimulated IRE1alpha activation in pancreatic beta-cells. Science Signaling 3, ra7 (2010).
5. Bo Shan, Xiaoxia Wang, Ying Wu, Chi Xu, Zhixiong Xia, Jianli Dai, Mengle Shao, Feng Zhao, Shengqi He, Liu Yang, Mingliang Zhang, Fajun Nan, Jia Li, Jianmiao Liu, Jianfeng Liu, Weiping Jia, Yifu Qiu, Baoliang Song, Jing-Dong J Han, Liangyou Rui, Sheng-Zhong Duan, Yong Liu. The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nature Immunology. 2017 May;18(5):519-529.
6. Xiao-Yu Tian, Kirthana Ganeshan, Cynthia Hong, Khoa D. Nguyen, Yifu Qiu, Jason Kim, Rajendra K. Tangirala, Peter Tonotonoz, Ajay Chawla. Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance. Cell Metabolism, 23, 1–14, (2016).
7. Min-Woo Lee, Justin I Odegaard, Lata Mukundan, Yifu Qiu, Ari B Molofsky, Jesse C Nussbaum, Karen Yun, Richard M Locksley, Ajay Chawla. Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis. Cell, 160, 74–87 (2015).
8. Mengle Shao, Bo Shan,Yang Liu, Yiping Deng, Cheng Yan, Ying Wu, Ting Mao, Yifu Qiu, Yubo Zhou, Shan Jiang, Weiping Jia, Jingya Li, Jia Li, Liangyou Rui, Liu Yang and Yong Liu. Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling. Nature Communications, 5:3528 (2014).
9. Amin Khalifeh Soltani, William McKleroy, Stephen Sakuma, Yuk Yin Cheung, Kevin Tharp, Yifu Qiu, Andreas Stahl, Ajay Chawla, and Kamran Atabai. Mfge8 is a central regulator of fatty acid uptake and obesity. Nature Medicine, 20(2):175-83 (2014).
10. Khoa D. Nguyen, Sarah J. Fentress, Yifu Qiu, Karen Yun, Jeffery S. Cox, Ajay Chawla. Circadian gene Bmal1 regulates diurnal oscillations to Ly6Chi inflammatory monocytes. Science, 341, 1483-1488 (2013). (Research Article).