教授
个人简介
研究主要运用恒河猴作为人类近缘模式动物的优势，开展人类演化与脑科学研究。近年来将前沿的生物信息学方法、分子演化理论和多组学研究策略引入非人灵长类领域，在探究人类特有基因与调控的起源与功能，揭示人脑演化规律、发现重大疾病新靶点等方面取得系列成果。入选中组部“万人计划”青年拔尖人才, 获国家“优秀青年科学基金”等支持，获“贝时璋青年生物物理学家奖”等奖项，指导的博士生获“吴瑞奖”等。担任中国动物学会灵长类学分会理事、中国实验动物学会灵长类专业委员会常务委员等。
所授课程
本科生/研究生：
《基因组医学基础》（选修，2学分，获威斯尼斯人615CC棋牌教学优秀奖）
《高级基因组医学》（选修，3学分）
教育背景
1999-2003 北京理工大学生命科学学院 本科
2007.9 – 2008.10 美国国立医学研究中心（NIH）交换学生 导师：George Uhl
2004.9-2009.2 威斯尼斯人615CC棋牌生命科学学院 博士 导师：魏丽萍
工作简历
2009.3 –2010.12 威斯尼斯人615CC棋牌生命科学学院 博士后
2011.1 –2019.7 威斯尼斯人615CC棋牌分子医学研究所 研究员
2019.8 –现在 威斯尼斯人615CC棋牌未来技术学院分子医学研究所 教授
承担项目
n 北京脑科学与类脑研究中心科研合作项目，人类特有调控在人脑发育中的功能探究，2021/01-2023/12
n 国家重点研发计划，2019YFA0801800，远程器官与骨髓的代谢特征及对话基础，2019/12-2024/11，
n 国家重点研发计划，2018YFA0801405，发育、代谢复杂疾病灵长类动物模型的创制与临床前研究，2019/11-2024/10
n 国家自然科学基金，31871272，基于全长转录谱的人类、恒河猴比较基因组学研究，2019/01-2022/12
代表性论文
1. Li Yumei#, Shen Qing S#, Peng Qi#, Ding Wanqiu, Zhang Jie, Zhong Xiaoming, An Ni A, Ji Mingjun, Zhou Wei-Zhen, Li Chuan-Yun*; Polyadenylation-related isoform switching in human evolution revealed by full-length transcript structure, Briefings in Bioinformatics, 2021, bbab157
2. Shao Li Wa#; Peng Qi#; Dong Mingyue; Gao Kaiyu; Li Yumei; Li Yi; Li Chuan Yun*; Liu Ying*; Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity, Nature Communications, 2020, 11(1): 0-4639.
3. An Ni A#; Ding Wanqiu#; Yang Xin Zhuang#; Peng Jiguang; He Bin Z; Shen Qing S; Lu Fujian; He Aibin; Zhang Yong E; Tan Bertrand Chin Ming; Chen Jia Yu*; Li Chuan Yun*; Evolutionarily significant A-to-I RNA editing events originated through G-to-A mutations in primates, Genome Biology, 2019, 20(1):0-24.
4. Li Yumei#; Ai Shanshan#; Yu Xianhong#; Li Chen; Li Xin; Yue Yanzhu; Wei Yusheng; Li Chuan Yun*; He Aibin*; Replication-Independent Histone Turnover Underlines the Epigenetic Homeostasis in Adult Heart, Circulation Research, 2019, 125(2): 198-208.
5. Li Yumei#; Li Chen#; Li Shuxian; Peng Qi; An Ni A; He Aibin*; Li Chuan Yun*; Human exonization through differential nucleosome occupancy, Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(35): 8817-8822.
6. Xiao Yao#; Wang Can#; Chen Jia Yu; Lu Fujian; Wang Jue; Hou Ning; Hu Xiaomin; Zeng Fanxin; Ma Dongwei; Sun Xueting; Ding Yi; Zhang Yan; Zheng Wen; Liu Yuli; Shang Haibao; Zhu Wenzhen; Han Chensheng; Zhang Yulin; Ouyang Kunfu; Chen Liangyi; Chen Ju; Xiao Rui Ping; Li Chuan Yun*; Zhang Xiuqin*; Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders, Nature Communications, 2018, 9(1): 0-2015.
7. Zhang Shi Jian#; Wang Chenqu#; Yan Shouyu; Fu Aisi; Luan Xuke; Li Yumei; Shen Qing S; Zhong Xiaoming; Chen Jia Yu; Wang Xiangfeng; Tan Bertrand Chin Ming; He Aibin; Li Chuan Yun*; Isoform Evolution in Primates through Independent Combination of Alternative RNA Processing Events, Molecular Biology and Evolution, 2017, 34(10): 2453-2468.
8. Lei Lei#; Yan Shou Yu#; Yang Ran; Chen Jia Yu; Li Yumei; Bu Ye; Chang Nannan; Zhou Qinchao; Zhu Xiaojun; Li Chuan Yun*; Xiong Jing Wei*; Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors, Nucleic Acids Research, 2017, 45(6): 3422-3436.
9. Zhong Xiaoming#; Peng Jiguang#; Shen Qing S#; Chen Jia Yu; Gao Han; Luan Xuke; Yan Shouyu; Huang Xin; Zhang Shi Jian; Xu Luying; Zhang Xiuqin; Tan Bertrand Chin Ming; Li Chuan Yun*; RhesusBase PopGateway: Genome-Wide Population Genetics Atlas in Rhesus Macaque, Molecular Biology and Evolution, 2016, 33(5): 1370-5.
10. Yang Xin Zhuang#; Chen Jia Yu#; Liu Chu Jun; Peng Jiguang; Wee Yin Rei; Han Xiaorui; Wang Chenqu; Zhong Xiaoming; Shen Qing S; Liu Hsuan; Cao Huiqing; Chen Xiao Wei; Tan Bertrand Chin-Ming*; Li Chuan Yun*; Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates, Molecular Biology and Evolution, 2015, 32(12): 3143-3157.
11. Chen Jia Yu#; Shen Qing S#; Zhou Wei Zhen#; Peng Jiguang; He Bin Z; Li Yumei; Liu Chu Jun; Luan Xuke; Ding Wanqiu; Li Shuxian; Chen Chunyan; Tan Bertrand Chin Ming; Zhang Yong E; He Aibin*; Li Chuan-Yun*; Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates, PLoS Genetics, 2015, 11(7).
12. Zhang Shi Jian#; Liu Chu Jun#; Yu Peng#; Zhong Xiaoming; Chen Jia Yu; Yang Xin Zhuang; Peng Jiguang; Yan Shouyu; Wang Chenqu; Zhu Xiaotong; Xiong Jingwei; Zhang Yong E; Tan Bertrand Chin Ming; Li Chuan Yun*; Evolutionary Interrogation of Human Biology in Well-annotated Genomic Framework of Rhesus Macaque, Molecular Biology and Evolution, 2014, 31(5): 1309-1324.
13. Chen Jia Yu#; Peng Zhiyu#; Zhang Rongli#; Yang Xin Zhuang; Tan Bertrand Chin Ming; Fang Huaying; Liu Chu Jun; Shi Mingming; Ye Zhi Qiang; Zhang Yong E; Deng Minghua; Zhang Xiuqin*; Li Chuan Yun*; RNA Editome in Rhesus Macaque Shaped by Purifying Selection, PLoS Genetics, 2014, 10(4).
14. Zhang Shi Jian#; Liu Chu Jun#; Shi Mingming#; Kong Lei; Chen Jia Yu; Zhou Wei Zhen; Zhu Xiaotong; Yu Peng; Wang Jue; Yang Xin Zhuang; Hou Ning.; Ye Zhiqiang; Zhang Rongli; Xiao Ruiping; Zhang Xiuqin*; Li Chuan Yun*; RhesusBase: a knowledgebase for the monkey research community, Nucleic Acids Research, 2013, 41(D1): 892-905.
15. Xie Chen#; Zhang Yong#; Chen Jia Yu#; Liu Chu Jun; Zhou Wei Zhen; Li Ying; Zhang Mao; Zhang Rongli; Wei Liping*; Li Chuan Yun*; Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs, PLoS Genetics, 2012, 8(9).